|
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The TREM2 variant is associated with: (i) AD (odds ratio: 4.76; P = .014); (ii) increased density of amyloid plaques and neurofibrillary tangles in multiple brain regions; (iii) increased TREM2 (P = .041) and TYROBP (P = .006) gene expression; (iv) decreased TREM2 protein levels (P = .016); and (v) upregulation of proinflammatory cytokines (regulated on activation, normal T cell expressed and secreted [RANTES] and interferon [IFN] gamma) (P = .003) and nominal downregulation of protective markers (α2-macroglobulin, interleukin 4 or IL-4, and ApoA1) (P = .018).
|
25499537 |
2015 |
|
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The relative expression level of BACE1 gene in the stem cell treatment group was lower than that in the AD control group (P<0.05), but that of A2M gene was increased (P<0.05).
|
30542456 |
2018 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our data suggest that attenuation of IL-1beta-induced alpha(2)M synthesis/release by blocking NF-kappaB activation may potentially be 'protective' against the development of late-onset AD.
|
12399113 |
2002 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genetic association between alpha-2 macroglobulin and Japanese sporadic Alzheimer's disease.
|
10477120 |
1999 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
|
9811940 |
1998 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Collectively these novel findings suggest that A2M is associated with preclinical AD, reflects early neuronal injury in the disease course and may be responsive to tau phosphorylation in the brain through the RCAN1-calcineurin pathway.
|
27872486 |
2017 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the subunit and conformational structure of alpha(2)M in AD plasma samples, and its capacity to bind trypsin, transforming growth factor-beta1, and Abeta.
|
14678766 |
2003 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In the brain of Alzheimer's disease (AD) patients, alpha(2)M has been localized to diffuse amyloid plaques. alpha(2)M also binds soluble beta-amyloid, of which it mediates degradation.
|
10959035 |
2000 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
LHGDN |
Through combination-analysis of the data about the A2M-I/D and the A2M-Ile1000Val variants, the A2M gene was suggested to be associated with Alzheimer's disease.
|
15931081 |
2005 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We conclude that there is no genetic association between A2M and AD in our case-control sample.
|
10462112 |
1999 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
|
9697696 |
1998 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Low-density lipoprotein receptor-related protein 1 (LRP1) and alpha-2-macroglobulin (A2M) are two plausible candidate genes for Alzheimer disease (AD) based on their important biological function and positional information.
|
16040006 |
2005 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
|
9697696 |
1998 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We recently reported that alpha-2 macroglobulin (A2M) is a biomarker of neuronal injury in Alzheimer's disease (AD) and identified a network of nine genes co-expressed with A2M in the brain.
|
29154276 |
2018 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E (apoE), the lipoprotein receptor related protein (LRP) and alpha-2 macroglobulin (alpha2M) have been proposed as a functional complex involved in amyloid clearance, a crucial event for Alzheimer's disease development.
|
10961667 |
2000 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We conclude that the BBB removes Ass from the brain largely via age-dependent, LRP-1-mediated transport that is influenced by alpha(2)M and/or apoE, and may be impaired in AD.
|
11120756 |
2000 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
The presence of MPO-G/G and A2M-Val/Val genotypes synergistically increased the risk of AD (OR, 25.5; 95% CI, 4.65-139.75).
|
15023809 |
2004 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The presence of MPO-G/G and A2M-Val/Val genotypes synergistically increased the risk of AD (OR, 25.5; 95% CI, 4.65-139.75).
|
15023809 |
2004 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The deletion polymorphism and Val1000Ile in alpha-2-macroglobulin and Alzheimer disease in Caribbean Hispanics.
|
10688047 |
2000 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings do not support the fact that the previously reported positive association between A2M deletion polymorphism and AD modifies the disease risk in the studied population.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:775-777, 2000.
|
11121179 |
2000 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results indicated that A2M-D allele was probably a weak AD protective factor, and there was a possible interaction of APOE-epsilon 4 and A2M-G alleles to increase AD risk in Mainland Han Chinese.
|
14675603 |
2004 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results from this study indicate that polymorphisms in LRP and A2M are not associated with increased risk for AD in Northern Ireland.
|
11496365 |
2001 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results failed to demonstrate an association between this polymorphism and Japanese sporadic AD, and the A2M I1000V mutation does not seem to be a risk factor per se for sporadic AD.
|
10936700 |
2000 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
On the lack of a clear-cut association between alpha-2-macroglobulin deletion and the risk of Alzheimer disease in Poland.
|
25574746 |
2014 |